Antirhinoviral activity of heterocyclic analogs of Win 54954.
J Med Chem
; 35(24): 4628-33, 1992 Nov 27.
Article
em En
| MEDLINE
| ID: mdl-1335079
ABSTRACT
A variety of heterocyclic analogs of Win 54954 have been synthesized and tested in vitro against human rhinovirus type 14 (HRV-14) in a plaque reduction assay. The more active compounds were tested against 14 additional serotypes, and the concentration which inhibited 80% of the serotypes tested (MIC80) was measured. One compound, 37, exhibited activity comparable to Win 59454. Physicochemical as well as electrostatic parameters were calculated and the results subjected to a QSAR analysis in an effort to explain differences in activity observed between these compounds; however, no meaningful correlation with biological activity was found with any of these parameters.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Rhinovirus
/
Tetrazóis
/
Isoxazóis
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article