Retinoids selective for retinoid X receptor response pathways.
Science
; 258(5090): 1944-6, 1992 Dec 18.
Article
em En
| MEDLINE
| ID: mdl-1335166
ABSTRACT
Retinoids have a broad spectrum of biological activities and are useful therapeutic agents. Their physiological activities are mediated by two types of receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs). RARs, as well as several related receptors, require heterodimerization with RXRs for effective DNA binding and function. However, in the presence of 9-cis-retinoic acid, a ligand for both RARs and RXRs, RXRs can also form homodimers. A series of retinoids is reported that selectively activates RXR homodimers but does not affect RAR-RXR heterodimers and thus demonstrates that both retinoid response pathways can be independently activated.
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Base de dados:
MEDLINE
Assunto principal:
Retinoides
/
Fatores de Transcrição
/
Receptores do Ácido Retinoico
/
Receptores de Superfície Celular
Limite:
Animals
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article