The erbB-3 gene in human pancreatic cancer.
J Pathol
; 168(3): 269-73, 1992 Nov.
Article
em En
| MEDLINE
| ID: mdl-1361525
ABSTRACT
Abnormalities of the type 1 growth factor receptor family have been implicated in the pathogenesis of pancreatic cancer. There is evidence for a potential autocrine loop involving overexpression of the epidermal growth factor (EGF) receptor and its ligands, as well as overexpression of the erbB-2 receptor. A third member of this receptor family, erbB-3, has recently been recognized and found to be abnormally expressed in some types of human cancer. In this study we show that overexpression of the erbB-3 protein occurs very frequently in carcinoma of the exocrine pancreas and also in chronic pancreatitis. We found no evidence of amplification or rearrangement of the erbB-3 gene by Southern blot analysis of DNA from pancreatic cancer cells lines.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Expressão Gênica
/
Proteínas Oncogênicas de Retroviridae
/
Proteínas Proto-Oncogênicas
Limite:
Humans
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article