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Determination of meprobamate in pharmaceutical dosage forms also containing carbromal by liquid chromatography and indirect photometric detection.
Bechet, I; Ceccato, A; Hubert, P; Herné, P; Crommen, J.
Afiliação
  • Bechet I; Laboratory of Drug Analysis, University of Liège, Belgium.
J Pharm Biomed Anal ; 10(10-12): 995-9, 1992.
Article em En | MEDLINE | ID: mdl-1363691
ABSTRACT
In a pharmaceutical form also containing carbromal, meprobamate could not be quantified selectively by classical methods described in pharmacopoeias due to a significant interference from carbromal. Consequently, reversed-phase HPLC methods have been developed to separate the two active ingredients using indirect photometric detection to visualize and determine meprobamate which has very poor chromophoric properties. Different parameters influencing the sensitivity of the indirect response, such as the nature of the highly absorbing compound added to the mobile phase (the marker) as well as the methanol content and the pH of this phase, have been studied. Two chromatographic systems containing benzoic acid or cinnamic acid as the marker, have been optimized and validated. Good linearity and reproducibility have been obtained with both systems but the cinnamic acid method has the advantage that meprobamate and carbromal can be determined simultaneously at 273 nm.
Assuntos
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Base de dados: MEDLINE Assunto principal: Ureia / Cromatografia Líquida de Alta Pressão / Meprobamato Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 1992 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Ureia / Cromatografia Líquida de Alta Pressão / Meprobamato Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 1992 Tipo de documento: Article