Synthesis, immunological activity and theoretical study of new 5-substituted 3-methylisoxazole[5,4-d] 1,2,3-triazin-4-one derivatives.
Acta Pol Pharm
; 60(2): 147-50, 2003.
Article
em En
| MEDLINE
| ID: mdl-13678327
ABSTRACT
A new series of 5-substituted 3-methylisoxazole[5,4-d] 1,2,3-triazin-4-one derivatives was prepared and investigated. The immunological activities of the studied compounds were investigated in two murine models of the immune response to sheep erythrocytes (SRBC)--the humoral immune response and delayed type hypersensitivity (DTH). Quantum-chemical calculations were carried out using AM1, a semiempirical method for geometry optimization, estimation of descriptors values and localization of the HOMO and LUMO orbitals.
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Base de dados:
MEDLINE
Assunto principal:
Triazinas
/
Isoxazóis
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article