A plasminogen-related gene is expressed in cancer cells.
Biochem Biophys Res Commun
; 186(2): 1108-14, 1992 Jul 31.
Article
em En
| MEDLINE
| ID: mdl-1379800
ABSTRACT
The breakdown of blood clots requires the fibrinolytic action of the serine proteinase plasmin, a two-chain polypeptide derived posttranslationally from its precursor zymogen, plasminogen. While investigating plasminogen gene expression in human extrahepatic tissues, a cDNA sequence was obtained which closely resembled the plasminogen cDNA, yet appeared to represent a distinct gene product. This sequence, which represents the transcript of the recently characterized plasminogen-related gene B, encodes a putative polypeptide of Mr 8800 and is expressed most prominently in malignant cancer cells.
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Base de dados:
MEDLINE
Assunto principal:
Plasminogênio
/
Neoplasias Ósseas
/
Osteossarcoma
/
Neoplasias Pulmonares
Limite:
Adult
/
Aged
/
Female
/
Humans
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article