Promoting effects of 6-mercaptopurine on carcinogenesis in various organs of F344 rats.
Cancer Lett
; 66(2): 147-53, 1992 Sep 30.
Article
em En
| MEDLINE
| ID: mdl-1394119
ABSTRACT
Possible promoting effects of 6-mercaptopurine (6-MP) on carcinogenesis in various organs, including the hematopoietic system, were investigated in female F344 rats, using a 2-stage carcinogenesis model. 6-MP was given as a dietary supplement (50 ppm) for 35 weeks subsequent to wide-spectrum initiation with N-ethyl-N-nitrosourea (ENU). Various tumors were observed in the carcinogen-initiated groups. No significant influence of 6-MP on their development, including the occurrence of leukemia, was apparent. However, the incidences of some proliferative lesions in the lung, intestine and kidney were slightly higher in the ENU/6-MP group than the ENU group. Further studies may be needed on promoting effects of 6-MP, based on dose-effect relation using several 6-MP doses and/or other initiators.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Carcinógenos
/
Mercaptopurina
/
Neoplasias Experimentais
Limite:
Animals
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article