[X-ray diffraction studies on tolbutamide solid dispersion].
Yao Xue Xue Bao
; 27(2): 144-9, 1992.
Article
em Zh
| MEDLINE
| ID: mdl-1414371
ABSTRACT
D860 (tolbutamide) solid dispersions prepared with urea, polyvinyl pyrrolidone (PVP), and polyethylene glycal (PEG) 6000 as carriers were studied by X-ray diffraction, relating to their dissolution rates. D860 in D860-PVP dispersion was shown to be in an amorphous state and to have greater dissolution rate. D860-urea and D860-PEG melts were found to be partly in miscible solid solution state and partly in microcrystal state and possess higher activity and greater dissolution rate. D860-PEG coprecipitate was a physical mixture and its dissolution rate is slower than its melt. No variation in the crystal structure of the D860 dispersions was observed during the ageing test.
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Base de dados:
MEDLINE
Assunto principal:
Tolbutamida
Idioma:
Zh
Ano de publicação:
1992
Tipo de documento:
Article