Ketamine blocks cortical epileptic afterdischarges but not paired-pulse and frequency potentiation.
Neuroscience
; 50(2): 339-44, 1992 Sep.
Article
em En
| MEDLINE
| ID: mdl-1436495
ABSTRACT
Cortical epileptiform afterdischarges (spike-and-wave rhythm) induced by low-frequency stimulation of the sensorimotor cortex were dose-dependently shortened by ketamine (10, 20 and 40 mg/kg, i.p.). Myoclonic jerking during stimulation was unaffected by ketamine whereas the same motor pattern accompanying afterdischarges was markedly suppressed by this drug. Paired-pulse as well as frequency potentiation of the cortical interhemispheric (transcallosal) responses were not significantly altered by the 40 mg/kg dose of ketamine. The two simple potentiation phenomena studied probably did not play a role in initiation of cortical epileptic afterdischarges.
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Base de dados:
MEDLINE
Assunto principal:
Córtex Cerebral
/
Epilepsia
/
Ketamina
/
Atividade Motora
Limite:
Animals
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article