Intracranial EEG study of brain structures affected by internal carotid injection of amobarbital.
Neurology
; 42(11): 2136-43, 1992 Nov.
Article
em En
| MEDLINE
| ID: mdl-1436524
ABSTRACT
Hippocampal function, considered critical in memory processing, is supposedly tested in the intracarotid sodium amobarbital (ISA) procedure; however, since the hippocampus is not completely irrigated by the internal carotid artery, some believe the procedure may be invalid for memory testing. We quantified delta activity in intracerebral EEGs during ISA tests. There was increased delta in ipsilateral structures as follows amygdala (6.4 minutes), anterior hippocampus (7.2), middle hippocampus (7.4), temporal neocortex (9.1), frontal lobe (8.4), central/parietal area (11.0), and occipital lobe (9.7). Contralateral structures usually (> 64%) showed increased delta lasting 4 to 5 minutes. The ipsilateral hippocampus had delta waves in over 90% of injections. We conclude that the hippocampus is clearly affected by the ISA injection. We argue that the slow waves may not be caused by a direct effect of the drug, but rather by a functional deafferentation due to the profound inactivation of structures surrounding the hippocampus. Similarly, slow waves contralateral to injection may be caused by sudden removal of neuronal input from the regions receiving the amobarbital.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Artéria Carótida Interna
/
Eletroencefalografia
/
Amobarbital
Limite:
Humans
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article