Inhibition of rat tissue kallikrein gene family members by rat kallikrein-binding protein and alpha 1-proteinase inhibitor.
FEBS Lett
; 309(3): 405-8, 1992 Sep 14.
Article
em En
| MEDLINE
| ID: mdl-1445595
ABSTRACT
The regulation of tissue kallikrein activity by plasma serine proteinase inhibitors (serpins) was investigated by measuring the association rate constants of six tissue-kallikrein family members isolated from the rat submandibular gland, with rat kallikrein-binding protein (rKBP) and alpha 1-proteinase inhibitor (alpha 1-PI). Both these serpins inhibited kallikreins rK2, rK7, rK8, rK9 and rK10 with association rate constants in the 10(3)-10(4) M-1.s-1 range, whereas only 'true' tissue kallikrein rK1 was not susceptible to alpha 1-PI. This results in slow inhibition of rK1 by plasma serpins, which could explain why this kallikrein is the only member of the gene family identified so far that induces a transient decrease in blood pressure when injected in minute amounts into the circulation.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Calicreínas
/
Receptores Imunológicos
/
Alfa 1-Antitripsina
/
Família Multigênica
Limite:
Animals
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article