Molecular basis of alpha-tocopherol inhibition of smooth muscle cell proliferation in vitro.
EXS
; 62: 164-77, 1992.
Article
em En
| MEDLINE
| ID: mdl-1450584
ABSTRACT
The molecular events responsible for the inhibition of cell proliferation by alpha-tocopherol have been investigated. Smooth muscle cells in vitro have been shown to be specifically inhibited by alpha-tocopherol with a concomitant inhibition of protein kinase C activity. beta-Tocopherol was inactive, despite its similar radical scavenging activity. The point of inhibition of alpha-tocopherol relative to the cell cycle was localized in the late G1 phase. A second effect of alpha-tocopherol observed with smooth muscle cells was the stimulation of protein kinase C biosynthesis in both the S and G2 phases of the cell cycle. The implications of these findings for the onset of arteriosclerosis are discussed.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Vitamina E
/
Divisão Celular
/
Músculo Liso Vascular
Limite:
Animals
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article