[A comparative study of the development of trisomy 21 concepti and the growth of their cells in vitro]. / Etude comparative du developpement des conceptus trisomiques 21 et de la croissance in vitro de leurs cellules.

Children with trisomy 21 are only a part of conceptuses with this anomaly which leads mainly to early arrests of development. Growth retardation of embryo and placenta are the main characteristics of these abortuses. Cell lines were established from tissues of trisomics 21 of different types of evolution (early spontaneous abortions, abortions after prenatal diagnosis, stillbirths and newborn-infants). Differences in the in vitro growth characteristics of these cells have been evidenced. They may explain the variations in the developmental potentials of trisomy 21 conceptuses.