Local anesthetic-induced toxicity may be modified by low doses of flumazenil.
Life Sci
; 51(25): I-IV, 1992.
Article
em En
| MEDLINE
| ID: mdl-1453872
ABSTRACT
The purpose of this study was to investigate the influence of flumazenil on local anesthetic-induced acute toxicity. For each of the three tested anesthetics (etidocaine, mepivacaine and lidocaine) 6 groups of mice were treated by a single dose of flumazenil (0.125, 0.25, 0.5, 1 and 2 mg/kg), or an equal volume of saline, 15 minutes before the injection of the anesthetic (etidocaine 50 mg/kg, mepivacaine 110 mg/kg and lidocaine 115 mg/kg). The convulsant activity, the time of latency to convulse and the mortality rate were assessed in each group. The local anesthetic-induced mortality was not significantly modified by flumazenil. The convulsant activity of lidocaine and mepivacaine was significantly increased by flumazenil but not for etidocaine. Also, increasing doses of flumazenil decreased the time of latency to obtain lidocaine-induced convulsions. This effect was not obtained with etidocaine or mepivacaine.
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Base de dados:
MEDLINE
Assunto principal:
Flumazenil
/
Etidocaína
/
Anestesia Local
/
Lidocaína
/
Mepivacaína
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article