Manadomanzamines A and B: a novel alkaloid ring system with potent activity against mycobacteria and HIV-1.
J Am Chem Soc
; 125(44): 13382-6, 2003 Nov 05.
Article
em En
| MEDLINE
| ID: mdl-14583033
ABSTRACT
Two novel alkaloids, named manadomanzamines A (1) and B (2), were isolated from an Indonesian sponge Acanthostrongylophora sp. (Haplosclerida Petrosiidae). Their structures were elucidated and shown to be a novel organic skeleton related to the manzamine type alkaloids. Their absolute configuration and conformation were determined by CD, NOESY, and molecular modeling analysis. The microbial community analysis for the sponge that produces these unprecedented alkaloids has also been completed. Manadomanzamines A (1) and B (2) exhibited strong activity against Mycobacterium tuberculosis (Mtb) with MIC values of 1.9 and 1.5 mug/mL, respectively. Manadomanzamines A and B also exhibit activities against human immunodeficiency virus (HIV-1) and AIDS opportunistic fungal infections.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
HIV-1
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Alcaloides Indólicos
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Alcaloides
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Mycobacterium tuberculosis
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article