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Consistent disruption of the AML1 gene occurs within a single intron in the t(8;21) chromosomal translocation.
Shimizu, K; Miyoshi, H; Kozu, T; Nagata, J; Enomoto, K; Maseki, N; Kaneko, Y; Ohki, M.
Afiliação
  • Shimizu K; Department of Immunology and Virology, Saitama Cancer Center Research Institute, Japan.
Cancer Res ; 52(24): 6945-8, 1992 Dec 15.
Article em En | MEDLINE | ID: mdl-1458484
The AML1 gene on chromosome 21 was rearranged by the t(8;21) chromosomal translocation in acute myeloid leukemia (AML). Southern blot analysis of 21 AML patients with t(8;21), including three with complex translocations, t(8;V;21), demonstrated that all the breakpoints occurred at random within a single intron between two coding exons of AML1. Clustering of the breakpoints in the restricted intron suggests the formation of a unique fusion gene between the AML1 gene and a presumable counterpart gene on chromosome 8. Nucleotide sequencing of the breakpoint region revealed that the translocation event was accompanied by deletion of a short stretch of nucleotides.
Assuntos
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Base de dados: MEDLINE Assunto principal: Oncogenes / Translocação Genética / Cromossomos Humanos Par 8 / Cromossomos Humanos Par 21 / Íntrons / Leucemia Mieloide Aguda Limite: Humans Idioma: En Ano de publicação: 1992 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Oncogenes / Translocação Genética / Cromossomos Humanos Par 8 / Cromossomos Humanos Par 21 / Íntrons / Leucemia Mieloide Aguda Limite: Humans Idioma: En Ano de publicação: 1992 Tipo de documento: Article