Design and synthesis of orally active inhibitors of TNF synthesis as anti-rheumatoid arthritis drugs.
Bioorg Med Chem Lett
; 13(22): 3951-4, 2003 Nov 17.
Article
em En
| MEDLINE
| ID: mdl-14592482
ABSTRACT
A novel series of TNF inhibitors was identified based on the screening of existing MMP inhibitor libraries. Further SAR optimization led to the discovery of a novel lead compound. Its synthesis, efficacy in experimental animal models, and pharmacokinetic data are discussed.
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Base de dados:
MEDLINE
Assunto principal:
Artrite Reumatoide
/
Fator de Necrose Tumoral alfa
/
Antirreumáticos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article