Synthesis and anticonvulsant and neurotoxicity evaluation of N4-phthalimido phenyl (thio) semicarbazides.
Eur J Pharm Sci
; 20(3): 341-6, 2003 Nov.
Article
em En
| MEDLINE
| ID: mdl-14592700
ABSTRACT
The phenyl (thio) semicarbazide derivatives of phthalimido pharmacophore were synthesized and evaluated for their anticonvulsant and neurotoxic properties. Initial anticonvulsant screening was performed using intraperitoneal (i.p.), maximal electroshock-induced seizure (MES), subcutaneous pentylenetetrazole (scPTZ) and subcutaneous strychnine (sc STY)-induced seizure threshold tests in mice. Compound 2c afforded protection in all the three screens. Compounds except 1d, 2a and 2d showed no neurotoxicity up to 300 mg/kg. Compounds 1a, 1b, 2c, 2d, 2g and 2i were found to show oral MES activity. The compounds exhibited CNS depression and behavioral despair side effects, lesser than the conventional antiepileptic drugs.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Semicarbazidas
/
Anticonvulsivantes
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article