Peptide-induced conformational changes in class I heavy chains alter major histocompatibility complex recognition.
J Exp Med
; 176(6): 1757-61, 1992 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-1460430
ABSTRACT
Small peptides, derived from endogenous proteins bind within the antigen binding groove created by the beta-pleated sheets and alpha helices of the alpha 1 and alpha 2 domains of the class I molecule of the major histocompatibility complex (MHC). However, the precise role of peptide in class I MHC conformation remains unclear. Here, we have shown that, in at least some instances, changes induced in the MHC molecule by the binding of distinct peptides can be identified as specific alterations in serological epitopes expressed on the class I protein. The nature of specific peptides expressed by class I-bearing cells may, therefore, have a dramatic influence on T cell development, self-tolerance, and alloreactivity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Conformação Proteica
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Antígenos de Histocompatibilidade Classe I
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Complexo Principal de Histocompatibilidade
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article