Absolute configuration and anticancer activity of taxiresinol and related lignans of Taxus wallichiana.

Chattopadhyay, Sunil K; Kumar, T R Santha; Maulik, Prakas R; Srivastava, Sachin; Garg, Ankur; Sharon, Ashoke; Negi, Arvind S; Khanuja, Suman Preet S

Chattopadhyay, Sunil K; Kumar, T R Santha; Maulik, Prakas R; Srivastava, Sachin; Garg, Ankur; Sharon, Ashoke; Negi, Arvind S; Khanuja, Suman Preet S.

Afiliação

Chattopadhyay SK; Central Institute of Medicinal and Aromatic Plants (CIMAP), PO CIMAP, -226 015, Lucknow, India. chattsk@yahoo.com

Bioorg Med Chem ; 11(23): 4945-8, 2003 Nov 17.

Article em En | MEDLINE | ID: mdl-14604656

ABSTRACT

ABSTRACT

Absolute configuration of taxiresinol 1, a lignan from the heartwood of Taxus wallichiana has been determined as 8R, 8'R, and 7'R with the help of chemical correlation method and X-ray crystallography. The anticancer activity of taxiresinol 1 and other two lignans 2, 3 were also studied. Taxiresinol 1 showed notable anticancer activity in the in vitro bioassays against colon, liver, ovarian and breast cancer cell lines.

Assuntos

Antineoplásicos Fitogênicos/química; Antineoplásicos Fitogênicos/farmacologia; Furanos/química; Furanos/farmacologia; Lignanas/química; Lignanas/farmacologia; Extratos Vegetais/química; Extratos Vegetais/farmacologia; Taxus/química; Linhagem Celular Tumoral; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Espectroscopia de Ressonância Magnética; Estrutura Molecular

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Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Lignanas / Taxus / Furanos / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Ano de publicação: 2003 Tipo de documento: Article

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