Molecular characterization and structural organization of D-elg, an ets proto-oncogene-related gene of Drosophila.
Oncogene
; 7(12): 2471-8, 1992 Dec.
Article
em En
| MEDLINE
| ID: mdl-1461651
ABSTRACT
We have continued the molecular analysis of D-elg, a member of the Drosophila ets gene family. Based on the characterization of cDNA and genomic sequences, the D-elg gene contains five exons and four introns and produces a mRNA with an open reading frame of 464 amino acids. Consistent with this analysis, in vitro translation of a near full-length D-elg cRNA yields a protein with a molecular weight of approximately 56 kDa. D-elg shows significant homology to other ets proteins in the amino-terminal A domain and strong homology in the carboxy-terminal ETS domain. The D-elg protein is most similar to the alpha-subunit of the mouse GA-binding protein.
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Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Proteínas Tirosina Quinases
/
Proto-Oncogenes
/
Família Multigênica
/
Proteínas Proto-Oncogênicas
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Proteínas de Drosophila
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Drosophila
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article