IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion.
J Immunol
; 171(11): 5727-35, 2003 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-14634080
ABSTRACT
Based primarily on in vitro data, IL-2 is believed to be the key cytokine for initiation of the cell cycle of activated T cells. However, the role of IL-2 remains unresolved for T cell responses in vivo. We examined whether the absence of IL-2-mediated signaling in CD8 T cells affected initiation of proliferation. Our results conclusively demonstrated that initial division of Ag-specific CD8 T cells following priming was IL-2 independent, regardless of the context in which Ag was presented. In contrast, the latter stage of the proliferative phase was IL-2-dependent, particularly in nonlymphoid tissues. Thus, activated CD8 T cells initially undergo IL-2-independent proliferation, but reach a critical juncture where the requirement for IL-2 as a growth factor gains prominence.
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Base de dados:
MEDLINE
Assunto principal:
Ciclo Celular
/
Interleucina-2
/
Linfócitos T CD8-Positivos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article