Chemistry of renieramycins. Part 3.(1) isolation and structure of stabilized renieramycin type derivatives possessing antitumor activity from Thai sponge Xestospongia species, pretreated with potassium cyanide.
J Nat Prod
; 66(11): 1441-6, 2003 Nov.
Article
em En
| MEDLINE
| ID: mdl-14640515
ABSTRACT
Renieramycins M (1m) and N (1n) were isolated from the Thai sponge Xestospongia sp., pretreated with potassium cyanide in methanolic buffer solution, and their structures and relative stereochemistries were elucidated on the basis of spectroscopic data. This strategy is the first example of the gram-scale preparation of this series of compounds and presents a potential solution for increasing the gram-scale supply of novel natural products from marine sources.
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Base de dados:
MEDLINE
Assunto principal:
Poríferos
/
Técnicas de Química Combinatória
/
Tetra-Hidroisoquinolinas
Limite:
Animals
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article