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Phenotypes indicating cytolytic properties of Borrelia-specific interferon-gamma secreting cells in chronic Lyme neuroborreliosis.
Ekerfelt, C; Jarefors, S; Tynngård, N; Hedlund, M; Sander, B; Bergström, S; Forsberg, P; Ernerudh, J.
Afiliação
  • Ekerfelt C; Division of Clinical Immunology, Department of Molecular and Clinical Medicine, University of Linköping, Linköping, Sweden. Christina.Ekerfelt@imk.liu.se
J Neuroimmunol ; 145(1-2): 115-26, 2003 Dec.
Article em En | MEDLINE | ID: mdl-14644037
The immuno-pathogenetic mechanisms underlying chronic Lyme neuroborreliosis are mainly unknown. Human Borrelia burgdorferi (Bb) infection is associated with Bb-specific secretion of interferon-gamma (IFN-gamma), which may be important for the elimination of Bb, but this may also cause tissue injury. In order to increase the understanding of the pathogenic mechanisms in chronic neuroborreliosis, we investigated which cell types that secrete IFN-gamma. Blood mononuclear cells from 13 patients with neuroborreliosis and/or acrodermatitis chronicum atrophicans were stimulated with Bb antigen and the phenotypes of the induced IFN-gamma-secreting cells were analyzed with three different approaches. Cells expressing CD8 or TCRgammadelta, which both have cytolytic properties, were the main phenotypes of IFN-gamma-secreting cells, indicating that tissue injury in chronic neuroborreliosis may be mediated by cytotoxic cells.
Assuntos
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Base de dados: MEDLINE Assunto principal: Leucócitos Mononucleares / Imunofenotipagem / Interferon gama / Neuroborreliose de Lyme / Borrelia burgdorferi / Citotoxicidade Imunológica Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2003 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Leucócitos Mononucleares / Imunofenotipagem / Interferon gama / Neuroborreliose de Lyme / Borrelia burgdorferi / Citotoxicidade Imunológica Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2003 Tipo de documento: Article