Dying for NF-kappaB? Control of cell death by transcriptional regulation of the apoptotic machinery.
Curr Opin Cell Biol
; 15(6): 732-7, 2003 Dec.
Article
em En
| MEDLINE
| ID: mdl-14644198
ABSTRACT
The transcription factor nuclear factor kappaB (NF-kappaB) is a pleiotropic protein complex that is activated from a sequestered, cytoplasmic form by pro-inflammatory extracellular signals and cellular stress. Several hundred cellular genes have been shown to be regulated by NF-kappaB, including cytokines, chemokines and adhesion molecules. Nearly eight years ago, a flurry of publications showed that loss or suppression of NF-kappaB results in an enhanced sensitivity to apoptosis. In the ensuing years, activation of NF-kappaB has become almost synonymous with enhanced cell survival, although more recent data suggests that this transcription factor plays a more complex role in the regulation of cell death.
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Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
NF-kappa B
/
Apoptose
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article