Cell-permeable small molecule probes for site-specific labeling of proteins.
Chem Commun (Camb)
; (23): 2870-1, 2003 Dec 07.
Article
em En
| MEDLINE
| ID: mdl-14680216
ABSTRACT
We have successfully synthesized a number of small molecule probes designed for site-specific labeling of N-terminal cysteine-containing proteins expressed in live cells. Their utility for site-specific, covalent modifications of proteins was successfully demonstrated with purified proteins in vitro, and with live bacterial cells in vivo.
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Base de dados:
MEDLINE
Assunto principal:
Sondas Moleculares
/
Proteínas
/
Permeabilidade da Membrana Celular
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article