Pain-related differential expression of NGF, GDNF, IL-6, and their receptors in human vasculitic neuropathies.
Intern Med
; 42(11): 1100-3, 2003 Nov.
Article
em En
| MEDLINE
| ID: mdl-14686749
ABSTRACT
OBJECTIVE:
Pain-related differential expressions of nerve growth factor (NGF), glial cell line-derived neurotrophic factor (GDNF) and interleukin-6 (IL-6), and their receptors were investigated in human vasculitic neuropathies. MATERIALS ANDMETHODS:
The mRNA levels of pain-related neurotrophic factors, NGF, GDNF and IL-6, were examined in the sural nerves of 22 painful and non-painful patients with acute necrotizing vasculitic neuropathies, together with their concomitant soluble receptors (p75, GFR(alpha)-1 and IL-6R(alpha)).RESULTS:
The mRNAs for these factors and receptors in the lesioned nerves were up-regulated to a variable extent in both groups. NGF mRNA expression was more closely correlated with that of p75 in painful neuropathy with relatively preserved large fiber density, compared with non-painful neuropathy, though the NGF mRNA level in painful neuropathy was lower than that in non-painful neuropathy. GDNF was closely associated with GFR(alpha)-1 in mRNA levels regardless of the pain state, but IL-6 was not associated with IL-6R(alpha).CONCLUSION:
The differential expression of neurotrophic factors and their cognate soluble receptors in human vasculitic neuropathy suggests that NGF, which was effectively transferred to sensory axons with p75, may induce pain.
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Base de dados:
MEDLINE
Assunto principal:
Poliarterite Nodosa
/
Síndrome de Churg-Strauss
/
Interleucina-6
/
Fator de Crescimento Neural
/
Fatores de Crescimento Neural
/
Neuralgia
Tipo de estudo:
Etiology_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article