Coenzyme Q differentially modulates phospholipid hydroperoxide glutathione peroxidase gene expression and free radicals production in malignant and non-malignant prostate cells.
Biofactors
; 18(1-4): 265-70, 2003.
Article
em En
| MEDLINE
| ID: mdl-14695942
ABSTRACT
The aim of this study was to investigate the role of coenzyme Q on the mRNA abundance of PHGPx and the reactive oxygen species (ROS) production in two different cell lines from human prostate, a line of non cancer cells (PNT2) and a line of cancer cells (PC3). Results showed that malignant cells markedly differ in their response to coenzyme Q compared to non-malignant cells, with no changes in PHGPx expression and greater ROS production. Furthermore coenzyme Q supplementation significantly lowered cell growth of the PC3 cancer line without affecting the PNT2. If these results are confirmed with additional experiments, it could represent a novel and interesting approach on the biomedical use of coenzyme Q10 in cancer therapy.
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Base de dados:
MEDLINE
Assunto principal:
Próstata
/
Neoplasias da Próstata
/
Regulação Enzimológica da Expressão Gênica
/
Ubiquinona
/
Radicais Livres
/
Glutationa Peroxidase
Limite:
Humans
/
Male
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article