Synthesis and antifungal activity of novel 14-membered benzomacrolides, as galbonolide analogues.
Chem Pharm Bull (Tokyo)
; 52(1): 163-5, 2004 Jan.
Article
em En
| MEDLINE
| ID: mdl-14709890
ABSTRACT
Asymmetric total synthesis of benzene analogues of galbonolide, a 14-membered antifungal macrolide, possessing a benzene ring instead of a conjugated diene structure, was achieved starting from chiral 1-aryl-1-propanol obtained by enzyme-catalyzed kinetic resolution with high enantioselectivity. Representatively, a method for the introduction of a methylthio and chloride function at the vinyl position was also established. The resulting analogues unfortunately exhibited very little antifungal potency in comparison with galbonolide A.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Macrolídeos
/
Lactonas
/
Antifúngicos
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article