Two tumour necrosis factor receptors: structure and function.
Trends Cell Biol
; 5(10): 392-9, 1995 Oct.
Article
em En
| MEDLINE
| ID: mdl-14732063
ABSTRACT
Tumour necrosis factor (TNF) exerts two main effects a beneficial one as an anti-infection, anti-tumour cytokine, and a detrimental one in the systemic inflammatory response syndrome (SIRS). Two receptors (TNF-R) mediate these effects, but their precise role in different cell types is far from solved. TNF induces receptor oligomerization, an event that is believed to connect the receptors to downstream signalling pathways. Recent research suggests that several TNF-R-associated proteins, including kinases, may initiate cytoplasmic signal transduction.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article