Hydrogen sulfide induces calcium waves in astrocytes.
FASEB J
; 18(3): 557-9, 2004 Mar.
Article
em En
| MEDLINE
| ID: mdl-14734631
ABSTRACT
Hydrogen sulfide (H2S) modifies hippocampal long-term potentiation (LTP) and functions as a neuromodulator. Here, we show that H2S increases intracellular Ca2+ and induces Ca2+ waves in primary cultures of astrocytes as well as hippocampal slices. H2S increases the influx of Ca2+ and to a lesser extent causes the release from intracellular Ca2+ stores. Ca2+ waves induced by neuronal excitation as well as responses to exogenously applied H2S are potently blocked by La3+ and Gd3+, inhibitors of Ca2+ channels. These observations suggest that H2S induces Ca2+ waves that propagate to neighboring astrocytes.
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Base de dados:
MEDLINE
Assunto principal:
Astrócitos
/
Sinalização do Cálcio
/
Sulfeto de Hidrogênio
Limite:
Animals
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article