Mitochondrial effectors in caspase-independent cell death.
FEBS Lett
; 557(1-3): 14-20, 2004 Jan 16.
Article
em En
| MEDLINE
| ID: mdl-14741334
ABSTRACT
Activation of caspases is recognized as a key element in the apoptotic process. However, new evidence is drawing attention to the emergent role of cell death pathways where caspases are not involved. Recent advances in the molecular understanding of these new ways to die, called caspase-independent, have revealed that mitochondria play an important role via the release of proapoptotic proteins. The purpose of this review is to integrate, from a biological and structural point of view, the most recent advances in the knowledge of the main mitochondrial proapoptotic proteins involved in this cell death cascade. The origin of programmed cell death is discussed through these strongly conserved effectors.
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Base de dados:
MEDLINE
Assunto principal:
Morte Celular
/
Apoptose
/
Caspases
/
Mitocôndrias
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article