Differential regulation of TCR-mediated gene transcription by Vav family members.
J Exp Med
; 199(3): 429-34, 2004 Feb 02.
Article
em En
| MEDLINE
| ID: mdl-14757747
ABSTRACT
Although all three Vav family members are expressed in T lymphocytes, the role that Vav3 plays in T cell activation is poorly defined. Here we show that, like Vav1, Vav3 undergoes rapid tyrosine phosphorylation after T cell receptor (TCR) cross-linkage and interacts with the adaptor molecules SLP76 and 3BP2 in a SH2-dependent manner. However, depletion of Vav1 but not Vav3 protein by RNA interference affects TCR-mediated IL-2 promoter activity. In contrast, Vav3 function is specifically required for coupling TCR stimulation to serum response element-mediated gene transcription. These data indicate that, although both Vav proteins are biochemically coupled to the TCR, they regulate distinct molecular pathways leading to defined gene transcriptional events.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores de Antígenos de Linfócitos T
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Linfócitos T
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Proteínas Oncogênicas
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Proteínas de Ciclo Celular
Limite:
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article