Acid-sensing ion channel 2 is important for retinal function and protects against light-induced retinal degeneration.
J Neurosci
; 24(5): 1005-12, 2004 Feb 04.
Article
em En
| MEDLINE
| ID: mdl-14762118
ABSTRACT
pH variations in the retina are thought to be involved in the fine-tuning of visual perception. We show that both photoreceptors and neurons of the mouse retina express the H+-gated cation channel subunits acid-sensing ion channel 2a (ASIC2a) and ASIC2b. Inactivation of the ASIC2 gene in mice leads to an increase in the rod electroretinogram a- and b-waves and thus to an enhanced gain of visual transduction. ASIC2 knock-out mice are also more sensitive to light-induced retinal degeneration. We suggest that ASIC2 is a negative modulator of rod phototransduction, and that functional ASIC2 channels are beneficial for the maintenance of retinal integrity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Retina
/
Degeneração Retiniana
/
Canais de Sódio
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Canais Iônicos
/
Luz
/
Proteínas de Membrana
/
Proteínas do Tecido Nervoso
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article