Aphidicolin selectively kills neuroblastoma cells in vitro.
Cancer Lett
; 67(2-3): 199-206, 1992 Dec 24.
Article
em En
| MEDLINE
| ID: mdl-1483268
ABSTRACT
Aphidicolin is a tetracyclic diterpene antibiotic which is known to inhibit the growth of eucaryotic cells by reversible binding to DNA polymerase alpha without significant effect on cell viability in most common human cell lines. We observed that aphidicolin at a concentration of 5 x 10(-7) M kills all cells of four human neuroblastoma cell lines. In contrast, viability of normal human embryonal cells and of human continuous cell lines including HeLa, H9, A549 and Caco-2 was influenced only moderately by aphidicolin. In addition, neuroblastoma cells were killed after treatment with 5 x 10(-7) M aphidicolin in cocultures with normal embryonal cells which continued to proliferate after removal of aphidicolin. These results show that aphidicolin provides an agent which selectively kills neuroblastoma cells in vitro.
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Base de dados:
MEDLINE
Assunto principal:
Afidicolina
/
Neuroblastoma
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article