CCL19 and CXCL12 trigger in vitro chemotaxis of human mantle cell lymphoma B cells.
Clin Cancer Res
; 10(3): 964-71, 2004 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-14871974
ABSTRACT
PURPOSE:
Few data are available in the literature on chemokine receptor expression and migratory capability of mantle cell lymphoma (MCL) B cells. Information on these issues may allow us to identify novel mechanisms of chemokine-driven tumor cell migration. EXPERIMENTALDESIGN:
The research was designed to investigate (a) expression of CCR1 to CCR7 and CXCR1 to CXCR5 chemokine receptors; and (b) chemotaxis to the respective ligands in MCL B cells and in their normal counterparts, i.e., CD5+ B cells.RESULTS:
Malignant B cells from MCL patients and normal counterparts displayed similar chemokine receptor profiles. MCL B cells were induced to migrate by CXCL12 and CCL19, whereas normal CD5+ B cells migrated to the former, but not the latter chemokine. Overnight culture of MCL B cells and their normal counterparts with CXCL12 cross-sensitized other chemokine receptors to their ligands in some tumor samples but not in CD5+ B cells.CONCLUSIONS:
CCR7 and CXCR4 ligands may play a key role in tumor cell migration and spreading in vivo. CXCL12 may additionally contribute by sensitizing MCL B cells to respond to the ligands of other chemokine receptors.
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Base de dados:
MEDLINE
Assunto principal:
Quimiotaxia
/
Linfoma de Células B
/
Quimiocinas CC
/
Quimiocinas CXC
/
Linfoma de Célula do Manto
Tipo de estudo:
Prognostic_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article