DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 2: C-terminal benzimidazoles and derivatives.
Bioorg Med Chem Lett
; 14(5): 1259-63, 2004 Mar 08.
Article
em En
| MEDLINE
| ID: mdl-14980677
ABSTRACT
The synthesis and in vitro potency of DNA minor-groove binding antibacterials lacking the C-terminal amide bond are described. The crescent shaped molecules bear the positively charged amino group at an internal pyrrole unit instead of the C-terminus. Three structural parameters were investigated the N-terminal unit, the internal amino group, and the C-terminal ring system. Several compounds demonstrated good in vitro potency against various Gram-positive bacteria and some molecules were moderately active against Escherichia coli, a representative Gram-negative strain.
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Base de dados:
MEDLINE
Assunto principal:
Benzimidazóis
/
DNA
/
Sistemas de Liberação de Medicamentos
/
Bactérias Gram-Positivas
/
Antibacterianos
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article