The Fes tyrosine kinase: a signal transducer that regulates myeloid-specific gene expression through transcriptional activation.
Blood Cells Mol Dis
; 32(2): 302-8, 2004.
Article
em En
| MEDLINE
| ID: mdl-15003822
ABSTRACT
The c-fps/fes protooncogene encodes a 92-kDa protein tyrosine kinase that is involved in myeloid cell development and immune responses of granulocytes and macrophages. To help define its biological role and mechanism of action, we have developed a gain of function allele of Fes that has potent biological activity in myeloid cells. Introduction of constitutively active Fes into myeloid progenitors induced the appearance of fully differentiated macrophages or granulocytes depending on the lineage commitment of the transduced cells. We found that Fes-induced macrophage differentiation correlated with activation of the ets family transcription factor PU.1, which is essential for macrophage development. On the other hand, granulocyte differentiation by Fes was mediated through activation of CCAAT/enhancer-binding protein alpha (C/EBP-alpha) and STAT3, two transcription factors that are critical for granulocytic differentiation. We postulate that Fes transduces inductive signals for terminal macrophage and granulocyte differentiation, and that this biological activity is mediated through the activation of lineage-specific transcription factors.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Tirosina Quinases
/
Transdução de Sinais
/
Ativação Transcricional
/
Proteínas de Fusão gag-onc
/
Células Mieloides
Limite:
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article