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Design and synthesis of a fluoroindolocarbazole series as selective topoisomerase I active agents. Discovery of water-soluble 3,9-difluoro-12,13-dihydro-13-[6-amino-beta-D-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with curative antitumor activity against prostate carcinoma xenograft tumor model.
Balasubramanian, Balu N; St Laurent, Denis R; Saulnier, Mark G; Long, Byron H; Bachand, Carol; Beaulieu, Francis; Clarke, Wendy; Deshpande, Milind; Eummer, Jeffrey; Fairchild, Craig R; Frennesson, David B; Kramer, Robert; Lee, Frank Y; Mahler, Mikael; Martel, Alain; Naidu, B Narasimhulu; Rose, William C; Russell, John; Ruediger, Edward; Solomon, Carola; Stoffan, Karen M; Wong, Henry; Wright, John J; Zimmermann, Kurt; Vyas, Dolatrai M.
Afiliação
  • Balasubramanian BN; The Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford Connecticut 06492, USA. balu@bms.com
J Med Chem ; 47(7): 1609-12, 2004 Mar 25.
Article em En | MEDLINE | ID: mdl-15027851
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Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Carbazóis / Inibidores da Topoisomerase I / Glucosídeos / Antineoplásicos Limite: Animals Idioma: En Ano de publicação: 2004 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Carbazóis / Inibidores da Topoisomerase I / Glucosídeos / Antineoplásicos Limite: Animals Idioma: En Ano de publicação: 2004 Tipo de documento: Article