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Nonparametric linkage analysis between schizophrenia and candidate genes of dopaminergic and serotonergic systems.
Ambrósio, Alda M; Kennedy, James L; Macciardi, Fabio; Coelho, Isabel; Soares, Maria J; Oliveira, Catarina R; Pato, Michele T; Pato, Carlos N.
Afiliação
  • Ambrósio AM; Department of Neurochemistry, University of Coimbra, Coimbra, Portugal. aldachico@yahoo.com
CNS Spectr ; 9(4): 302-8, 2004 Apr.
Article em En | MEDLINE | ID: mdl-15048055
ABSTRACT

BACKGROUND:

Alterations in dopaminergic and serotonergic systems have been implicated in the pathophysiology of schizophrenia for many years. This study was performed to assess the possible involvement of the dopamine receptor genes D2 (DRD2), D3, D4, serotonin receptor genes 1Da, 1Db, and 2A in the etiology of schizophrenia.

METHODS:

We examined 33 multiplex schizophrenic families from Portugal.

RESULTS:

Linkage analysis performed by GENEHUNTER showed nonsignificant linkage for these genes. A maximum nonparametric linkage score of 1.635 (P=.032) at DRD2 gene was observed, and this finding suggests DRD2 gene for further studies.

CONCLUSION:

the polymorphisms studied at dopamine receptor genes D3, D4, serotonin receptor genes 1Da, 1Db, and 2A do not have a major effect in susceptibility to schizophrenia in a Portuguese population.
Assuntos
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Base de dados: MEDLINE Assunto principal: Esquizofrenia / Dopamina / Serotonina / Ligação Genética Limite: Humans Idioma: En Ano de publicação: 2004 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Esquizofrenia / Dopamina / Serotonina / Ligação Genética Limite: Humans Idioma: En Ano de publicação: 2004 Tipo de documento: Article