Mechanical and thermal anti-nociception in rats after systemic administration of verapamil.
Neurosci Lett
; 360(1-2): 57-60, 2004 Apr 22.
Article
em En
| MEDLINE
| ID: mdl-15082178
ABSTRACT
Voltage-gated Ca(2+) channels expressed in neurons may contribute to nociceptive information processing. However, the role of L-type Ca(2+) channels in pain transmission is not well understood. In this study, we examined the effects of systemically administered verapamil, an antihypertensive agent and L-type Ca(2+) channel blocker, on mechanical and thermal withdrawal thresholds in rats. Intraperitoneal injections of verapamil induced dose-dependent (3-18 mg/kg) mechanical and thermal anti-nociception in adult rats without altering their sensorimotor abilities. Our data suggest that L-type Ca(2+) channels contribute to acute nociceptive signaling and that anti-nociceptive effects may result from the blockade of these channels.
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Base de dados:
MEDLINE
Assunto principal:
Tato
/
Medição da Dor
/
Verapamil
/
Temperatura Alta
/
Analgésicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article