Inflammatory pseudotumor of the spleen with EBV positivity: report of a case.
Eur J Haematol
; 72(4): 285-91, 2004 Apr.
Article
em En
| MEDLINE
| ID: mdl-15089768
ABSTRACT
Inflammatory pseudotumor (IPT) of the spleen is a rare benign tumor with unknown etiology. It causes problems in the diagnosis because of mimicking some hematopoetic malignancies. Here we report the case of a 36-yr-old woman complaining of nausea and insomnia. Laboratory investigations were limited to increase of leukocyte and thrombocyte count. Ultrasonography and magnetic resonance (MR) imaging showed circumscribed solid lobulated mass, measuring about 6.5 cm in diameter, located in the dorsal region of the spleen. Splenectomy was performed with the differential diagnosis including hamartoma and lymphoma of the spleen. Histological examination of the sharply demarcated splenic mass consisted of myofibroblasts and admixture of inflammatory cells. Immunohistochemistry and in situ hybridization were performed. IPT of the spleen was diagnosed. Epstein-Barr virus (EBV) was detected in the tumor by in situ hybridization. This rare entity is presented because of its clinical, radiological and pathological difficulties in the differential diagnosis.
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Base de dados:
MEDLINE
Assunto principal:
Esplenopatias
/
Herpesvirus Humano 4
/
Infecções por Vírus Epstein-Barr
/
Granuloma de Células Plasmáticas
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article