Relationship of structural magnetic resonance imaging, magnetic resonance perfusion, and other disease factors to neuropsychological outcome in sickle cell disease.
J Pediatr Psychol
; 29(2): 83-92, 2004 Mar.
Article
em En
| MEDLINE
| ID: mdl-15096530
ABSTRACT
OBJECTIVE:
To investigate the relationship between neuropsychological functioning and radiographic findings in children with sickle cell disease (SCD) with no history of clinical neurological events.METHODS:
Thirty-one patients with SCD randomly selected from a regional treatment center underwent neuropsychological and disease severity assessments. Of these, 22 also had structural magnetic resonance imaging and magnetic resonance perfusion studies performed.RESULTS:
Forty-five percent of the imaged subgroup showed imaging abnormalities that were found to be correlated with disease severity but not neuropsychological level of performance indices. A significant relationship, however, was found between imaging abnormalities and increased variability in neuropsychological performance.CONCLUSIONS:
These results corroborate the high rate of rheologic and vascular pathology in SCD and underscore the importance of representing neuropsychological functioning in multiple ways.
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Base de dados:
MEDLINE
Assunto principal:
Índice de Gravidade de Doença
/
Imageamento por Ressonância Magnética
/
Transtornos Cognitivos
/
Anemia Falciforme
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
País como assunto:
America do norte
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article