Primary murine cells as a model for HIV-1 infection.
AIDS
; 18(7): 1067-9, 2004 Apr 30.
Article
em En
| MEDLINE
| ID: mdl-15096811
ABSTRACT
Immortalized and transduced cell lines are traditionally used in model of the HIV-1 life cycle. Primary cells may better represent the tissue of origin and events in vivo. We utilized an HIV-1/murine leukemia A4070 pseudotype virus and human Cyclin T1 to replicate HIV-1 in primary murine cells, and demonstrate that primary murine cells support HIV-1 infection better than immortalized cells.
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Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
HIV-1
/
Modelos Animais de Doenças
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article