Aldosterone target organ protection by eplerenone.
Mol Cell Endocrinol
; 217(1-2): 229-38, 2004 Mar 31.
Article
em En
| MEDLINE
| ID: mdl-15134822
ABSTRACT
The classical mineralocorticoid effect of aldosterone on unidirectional transepithelial sodium transport in the kidney was long thought to be the predominant effect of this hormone. However, there is convincing evidence for additional extrarenal actions of aldosterone that are mediated via activation of mineralocorticoid receptors (MRs) in the heart, vasculature and brain. It is now postulated that many of the detrimental effects of aldosterone are mediated through MR activation in these nonclassical target organs. The selective aldosterone blocker, eplerenone (Inspra), is under development for human therapeutic use for treatment of hypertension and heart failure post-myocardial infarction (MI). Clinical and preclinical studies have linked elevated aldosterone to hypertension, left ventricular and vascular remodeling, cardiac, renal, and cerebral vascular inflammation and injury, and increased risk of mortality in heart failure patients. Multiple studies in experimental models of hypertension and heart failure demonstrate that selective blockade of aldosterone by eplerenone effectively preserves cardiac function, attenuates maladaptive left ventricular remodeling and tissue and vascular injury in part by reducing vascular inflammation in aldosterone target organs.
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Base de dados:
MEDLINE
Assunto principal:
Espironolactona
/
Remodelação Ventricular
/
Aldosterona
/
Antagonistas de Receptores de Mineralocorticoides
/
Insuficiência Cardíaca
/
Hipertensão
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article