CD40-associated TRAF 6 signaling is required for disease induction in a retrovirus-induced murine immunodeficiency.
J Virol
; 78(11): 6055-60, 2004 Jun.
Article
em En
| MEDLINE
| ID: mdl-15141004
ABSTRACT
LP-BM5 retrovirus-infected C57BL/6 mice develop splenomegaly, lymphadenopathy, hypergammaglobulinemia, and immunodeficiency; thus, this disease has been named mouse AIDS. In this syndrome, CD154/CD40 interactions are required for but do not mediate disease by upregulation of CD80 or CD86. We report here that there is nonetheless a necessity for CD40 signaling competence, specifically an intact tumor necrosis factor receptor-associated factor 6 (TRAF 6) binding site.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Síndrome de Imunodeficiência Adquirida Murina
/
Antígenos CD40
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article