Effect of herpes simplex virus type 1 infection on cytokine gene expression in activated murine peritoneal macrophages.
Adv Exp Med Biol
; 312: 167-72, 1992.
Article
em En
| MEDLINE
| ID: mdl-1514441
ABSTRACT
The intrinsic resistance to herpes simplex virus type 1 (HSV-1) of murine peritoneal macrophages (PM phi) obtained after in vivo infection of different stimuli has been investigated and shown to vary depending on the state of M phi activation. Activation of M phi by C. parvum (CP-M phi) or by an avirulent strain of S. typhimurium (Sal-M phi) increased the permissiveness of M phi to HSV-1 infection as evidenced by increased HSV-1 immediate early (IE) gene expression, synthesis of IE proteins, and the degree of cytopathic effect. HSV-1 infection was also found to sharply reduce the level of IL-1-beta mRNA in CP-M phi) and Sal-M phi, and the level of IL-3 mRNA in infected Sal-M phi, as measured by northern blot hybridization. Barely detectable levels of IL-beta mRNA were found in Sal-M phi after infection with HSV-1 when the polymerase chain reaction (PCR) assay was used to confirm the reduction of IL-1-beta mRNA. These data suggest that HSV-1 infection can modulate gene expression of some cytokines in the activated M phi.
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Base de dados:
MEDLINE
Assunto principal:
Expressão Gênica
/
Interleucinas
/
Herpes Simples
/
Ativação de Macrófagos
/
Macrófagos
Limite:
Animals
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article