Structure-based design, synthesis, and antimicrobial activity of purine derived SAH/MTA nucleosidase inhibitors.
Bioorg Med Chem Lett
; 14(12): 3165-8, 2004 Jun 21.
Article
em En
| MEDLINE
| ID: mdl-15149667
ABSTRACT
The structure-based design, synthesis, and biological activity of novel inhibitors of S-adenosyl homocysteine/methylthioadenosine (SAH/MTA) nucleosidase are described. Using 6-substituted purine and deaza purines as the core scaffolds, a systematic and structure guided series of modifications provided low nM inhibitors with broad-spectrum antimicrobial activity.
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Base de dados:
MEDLINE
Assunto principal:
Desenho de Fármacos
/
Inibidores Enzimáticos
/
Antibacterianos
/
N-Glicosil Hidrolases
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article