Polymer-coated liposomes resistant to enzymatic hydrolysis.
Biotechnol Lett
; 26(7): 611-4, 2004 Apr.
Article
em En
| MEDLINE
| ID: mdl-15168864
ABSTRACT
A polymerizable electrolyte, 2-aminoethyl 1,6-heptadien-4-yl phosphate (AEHDP), which has the same hydrophilic head group as naturally occurring phospholipids, was prepared. Five equivalents of AEHDP were added to a suspension of liposomes (closed bilayer vesicles made of phospholipids) and layered on the liposomes. After polymerization by UV irradiation, the resulting polymer-coated liposomes were resistant to hydrolysis of their constituent phospholipids by phospholipase A2.
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Base de dados:
MEDLINE
Assunto principal:
Fosfatidilcolinas
/
Fosfolipases A
/
Organofosfatos
/
Materiais Revestidos Biocompatíveis
/
Etanolaminas
/
Lipossomos
Tipo de estudo:
Evaluation_studies
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article