Synthesis and anticancer activity evaluation of new 2-alkylcarbonyl and 2-benzoyl-3-trifluoromethyl-quinoxaline 1,4-di-N-oxide derivatives.
Bioorg Med Chem
; 12(13): 3711-21, 2004 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-15186857
ABSTRACT
As a continuation of our research in quinoxaline 1,4-di-N-oxide and with the aim of obtaining new anticancer agents, which can improve the current chemotherapeutic treatments, new series of 2-alkylcarbonyl and 2-benzoyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide derivatives have been synthesized and evaluated for in vitro antitumor activity against a 3-cell line panel, consisting of MCF7 (breast), NCI-H460 (lung), and SF-268 (CNS). These active compounds were then evaluated in the full panel of 60 human tumor cell lines derived from nine cancer cell types. The results have shown that, in general, anticancer activity depends on the substituents in the carbonyl group, improving in the order ethyl
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Base de dados:
MEDLINE
Assunto principal:
Quinoxalinas
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article